[A cross oxidation of lipids and antioxidant erythrocyte defense barbotage aeroionization of the donor erythrocyte mass].

The possibility of the prolonged conservation of the native erythrocyte state of the donor erythrocyte mass with the use of barbotage aeronization was shown. The method of barbotage aero ionization, which was proposed by us in order to prolong the period of storage of donor erythrocytes, allows to decrease the level of destructive processed in storable erythrocyte mass, with the evidence of decrease in intensity of peroxidase lipid oxidation and growth of antioxidant activity in it.

[Antiarrhythmic activity of lidocaine under conditions of lipid and carbohydrate metabolisms disturbances in modeling early occlusional and reperfusional arrhythmias].

The antiarrhythmic activity of lidocaine on the models of early arrhythmias induced by occlusion and reperfusion was studied in rats with background derangements of lipidic and carbohydrate metabolisms. It was established that lidocaine in a dose of 100 mg/kg did not produce reliable antiarrhythmic action under these conditions. In addition, changes in the development of early occlusional and reperfusional arrhythmias against the background violation of lipid and carbohydrate metabolisms were found.

[The effect of rubomycin, mexidol and emoxypine on some metabolic indexes and the proccess of spontaneous metastasis under conditions of experimental neoplasia].

The effects of mexidol and emoxypine on some indexes of endotoxicosis and weighted characteristics of tumor carrier during experimental neoplasia have been studied under the conditions of therapy using antracycline antibiotic rubomycin.

Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism.

Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.

Arrhythmogenic effect of epinephrine during correction of dyslipidemia.

In rats with dyslipidemia epinephrine decreased HR and suppressed automaticity of the sinus node. This effect was not eliminated by LBK-149, dibunol, and glutabiance despite normalization of the plasma lipid spectrum. LBK-149 prevented the development of heart rhythm disturbances during epinephrine administration.

[The effect of ximedon on adaptation to prolonged immobilization stress]. / Vliianie ksimedona na adaptatsiiu k dlitel'nomu immobilizatsionnomu stressu.

It was shown in rabbit experiments that the use of ximedon in long-term immobilization stress limits activation of lipid peroxidation, stimulates the main enzymes of the antioxidant systems, causes of hypolipidemic, preventive endotheliotropic, and cardiotropic effect.

[Effect of UV-irradiation of blood on the course of adaptation to conditions of hypodynamia]. / Vliianie UF-oblucheniia krovi na techenie adaptatsii k usloviiam gipodinamii.

The rabbit experiment has studied the impact of ultraviolet (UV) blood irradiation on the course of adaptative processes under restrictive stress. Thirty-day hypodynamia was demonstrated to result in chronic stress whose pathogenetic links are activated neutrophilic leukocytes, developed disseminated intravascular coagulation, atherogenic metabolic changes. UV blood irradiation enhanced the body's adaptative potentialities under long-term hypodynamia, by diminishing restriction-induced stress lesion.

[Effect of oxygen aeroions on hemostasis and development of arteriosclerosis in hypodynamia]. / Vliianie aéroionov kisloroda na gemostaz i razvitie arterioskleroza pri gipodinamii.

Experiments on 50 rabbits examined the hemostatic effects of negative oxygen aeroions (AI). In control experiments, keeping the animals under hypodynamia led to 40% animal death, significant aortic atherosclerosis and myocardial infarction. The animals developed the thrombohemorrhagic syndrome with hypercoagulemia and drastically suppressed blood fibrinolytic activity. Keeping the animals in the excess AI-containing premise saved all rabbits' life and prevented arteriosclerosis and myocardial infarction. Unlike the controls, these animals failed to develop the thrombohemorrhagic syndrome. Clotting time, plasma recalcification time, and plasma silicon and kaolin time did not reduce, but prolonged. There was no drop in the content of antithrombin III or rise in values of paracoagulation tests. It is recommended that Chizhevsky's electroeffluvial chandeliers should be used to prevent hemostatic disorders and arteriosclerosis in hypodynamia.

[Adaptation to exercises after exposure to restriction stress]. / Adaptatsiia k fizicheskim nagruzkam posle vozdeistviia immobilizatsionnogo stressa.

Adaptation to exercises was studied in rabbits exposed to restriction stress. Transition from 30-day inactivity to the routine motor activity and subsequent exercises was found to cause a further progression of blood atherogenic changes, ulcerative arteriosclerosis, and heart failure.